Edited by internationally recognized authorities in the field, this expanded and updated new edition of the bestselling Handbook, containing many new articles, is aimed at the design and operation of modern particle accelerators. It is intended as a vade mecum for professional engineers and physicists engaged in these subjects. With a collection of more than 2000 equations, 300 illustrations and 500 graphs and tables, here one will find, in addition to common formulae of previous compilations, hard to find, specialized formulae, recipes and material data pooled from the lifetime experience of many of the world's most able practioners of the art and science of accelerators. The seven chapters include both theoretical and practical matters as well as an extensive glossary of accelerator types. Chapters on beam dynamics and electromagnetic and nuclear interactions deal with linear and nonlinear single particle and collective effects including spin motion, beam-environment, beam-beam, beam-electron, beam-ion and intrabeam interactions. The impedance concept and related calculations are dealt with at length as are the instabilities due to the various interactions mentioned. A chapter on operational considerations including discussions on the assessment and correction of orbit and optics errors, realtime feedbacks, generation of short photon pulses, bunch compression, phase-space exchange, tuning of normal and superconducting linacs, energy recovery linacs, free electron lasers, cryogenic vacuum systems, steady state microbuching, cooling, space-charge compensation, brightness of light sources, collider luminosity optimization and collision schemes, machine learning, multiple frequency rf systems, FEL seeding, ultrafast electron diffraction, and Gamma Factory. Chapters on mechanical and electrical considerations present material data and important aspects of component design including heat transfer and refrigeration. Hardware systems for particle sources, feedback systems, confinement, including undulators, and acceleration (both normal and superconducting) receive detailed treatment in a sub-systems chapter, beam measurement and apparatus being treated therein as well. A detailed name and subject index is provided together with reliable references to the literature where the most detailed information available on all subjects treated can be found.