Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology (Haschek and Rousseaux's Handbook of Toxicologic Pathology, nr. 1)

Editat de Wanda M. Haschek-Hock, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon
Notă GoodReads:
en Limba Engleză Hardback – 19 Apr 2022

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters.
Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.




  • Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations




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ISBN-13: 9780128210444
ISBN-10: 0128210443
Pagini: 1152
Ilustrații: Approx. 200 illustrations (200 in full color)
Dimensiuni: 216 x 276 mm
Greutate: 3.2 kg
Ediția: 4
Seria Haschek and Rousseaux's Handbook of Toxicologic Pathology


1. Toxicology Pathology: An Introduction
Part 1 Principles of Toxicologic Pathology 2. Biochemical and Molecular Basis of Toxicity 3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective 4. Biotherapeutic ADME and PK/PD Principles 5. Principles of Pharmacodynamics and Toxicodynamics 6. Morphologic Manifestations of Toxic Cell Injury 7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity 8. Carcinogenesis: Mechanisms and Evaluation
Part 2 Methods in Toxicologic Pathology 9. Basic Approaches to Anatomic Toxicologic Pathology 10. Clinical Pathology in Nonclinical Toxicity Testing 11. Special Techniques in Toxicologic Pathology 12. Digital Pathology and Tissue Image Analysis 13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models 14. Biomarkers: Discovery, Qualification and Application 15. Toxicogenomics: A Primer for Toxicologic Pathologists 16. Experimental Design and Statistical Analysis for Toxicologic Pathologists
Part 3 Animal and Alternative Models in Toxicologic Research 17. Animal Models in Toxicologic Research: Rodents 18. Animal Models in Toxicologic Research: Rabbit 19. Animal Models in Toxicologic Research: Dog 20. Animal Models in Toxicologic Research: Pig 21. Animal Models in Toxicologic Research: Nonhuman Primate 22. Animal Models in Toxicologic Research: Non-mammalian 23. Genetically Engineered Animal Models in Toxicologic Research 24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo Approaches
Part 4 Practice of Toxicologic Pathology 25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology 26. Pathology Peer Review 27. Pathology and GLPs, Quality Control and Quality Assurance 28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies 29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology