Health literacy in practice requires the development of techniques that ensure that the patient can better access information, understand its content, know how to use this information, and make better health decisions. If the patient makes better health decisions, there are immediate reflexes in health outcomes. The aim is to develop an approach based on the commitment and creation of an atmosphere of trust that reduces uncertainty, anxiety, and embarrassment based on a process of assertive, clear, and positive communication (ACP model). The Handbook of Research on Assertiveness, Clarity, and Positivity in Health Literacy brings the consolidation of knowledge, strategies, and techniques to improve health literacy. This book discusses the importance of making sound health decisions: decisions that can save lives, prevent premature deaths, avoid hospitalizations and abusive resources to medical emergencies, and improve overall health outcomes for the individual, family, community, and society. Covering topics such as dietary guidance, health behavior change models, and medication reconciliation, this resource has theoretical and practical aspects essential to health information libraries, hospitals, clinics, health centers, health schools, patient associations, health professionals, medical students, researchers, professors, and academicians.