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GPCRs: From Deorphanization to Lead Structure Identification de H. Bourne

GPCRs: From Deorphanization to Lead Structure Identification: Ernst Schering Foundation Symposium Proceedings, cartea 2006/2

Editat de H. Bourne, Richard Horuk, J. Kuhnke, H. Michel
en Limba Engleză Paperback – 30 noi 2010
Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by leading experts in the field, discussing the most recent state of the art. They give insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. The book reflects the actual trends in the fast-emerging field of GPCR research in academia and industry.
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Specificații

ISBN-13: 9783642080319
ISBN-10: 3642080316
Pagini: 288
Ilustrații: XVII, 269 p.
Dimensiuni: 130 x 210 x 15 mm
Greutate: 0.39 kg
Ediția:Softcover reprint of hardcover 1st ed. 2007
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Ernst Schering Foundation Symposium Proceedings

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

G-Proteins and GPCRs: From the Beginning.- Modeling GPCRs.- QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications.- Privileged Structures in GPCRs.- Designing Compound Libraries Targeting GPCRs.- Orphan Seven Transmembrane Receptor Screening.- The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling.- Deorphanization of G-Protein-Coupled Receptors.- Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target.- Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins.- High Content Screening to Monitor G Protein-Coupled Receptor Internalisation.- High-Throughput Lead Finding and Optimisation for GPCR Targets.