Genotoxicity Assessment
Editat de Alok Dhawan, Mahima Bajpayeeen Limba Engleză Hardback – 23 noi 2025
Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences.
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| Paperback (2) | 764.56 lei 6-8 săpt. | |
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| Springer – 2 sep 2020 | 856.50 lei 38-44 zile | |
| Hardback (3) | 1074.96 lei 6-8 săpt. | |
| Humana Press Inc. – 30 iul 2013 | 1074.96 lei 6-8 săpt. | |
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Specificații
ISBN-13: 9781071649756
ISBN-10: 1071649752
Pagini: 668
Ilustrații: XXVII, 643 p. 150 illus., 107 illus. in color.
Dimensiuni: 183 x 260 x 42 mm
Greutate: 1.37 kg
Ediția:Third Edition 2026
Editura: Humana
ISBN-10: 1071649752
Pagini: 668
Ilustrații: XXVII, 643 p. 150 illus., 107 illus. in color.
Dimensiuni: 183 x 260 x 42 mm
Greutate: 1.37 kg
Ediția:Third Edition 2026
Editura: Humana
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Cuprins
Bacterial Mutation Assays.- In Vitro Mouse Lymphoma (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay.- Erythrocyte--Based Pig--a Gene Mutation Assay.- Detection of in vivo Mutation in the Hprt and Pig--a Genes of Rat Lymphocytes.- In vivo cII, gpt, and Spi- gene Mutation Assays in Transgenic Mice and Rats.- In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests.- Analysis of Chromosome Aberrations in Somatic and Germ Cells of the Mouse.- Chromosomal Aberration Test in Human Lymphocytes.- In vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood.- Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells.- Flow Cytometric Determination of Micronucleus Frequency.- Fluorescent in situ Hybridization (FISH) Technique for the Micronucleus Test.- Comparative Genomic Hybridization (CGH) in Genotoxicology.- The in vitro Micronucleus Assay and Kinetochore Staining: Methodology and Criteria for the Accurate Assessment of Genotoxicity and Cytotoxicity.- g--H2AX Detection in Somatic and Germ Cells of Mice.- Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers.- The Comet Assay: Assessment of in vitro and in vivo DNA Damage.- The Comet Assay in Human Biomonitoring.- The Comet assay in Marine Animals.- Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo.- 32P--Postlabeling Analysis of DNA Adducts.- Micronucleus Assay with Tetrad Cells of Tradescantia.- The Wing--Spot and the Comet Tests as useful Assays Detecting Genotoxicity in Drosophila.- Genotoxicity Guidelines Recommended by International Conference of Harmonization (ICH).
Textul de pe ultima copertă
This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences.
Caracteristici
Describes comprehensive genetic toxicology protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts