Genes, Development and Cancer: The Life and Work of Edward B. Lewis
Editat de Howard D. Lipshitzen Limba Engleză Paperback – 12 oct 2007
The Second Edition has been expanded with new material and the commentaries have been updated.
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Specificații
ISBN-13: 9781402063435
ISBN-10: 1402063431
Pagini: 620
Ilustrații: XXI, 597 p.
Dimensiuni: 155 x 235 x 33 mm
Greutate: 1.06 kg
Ediția:2nd ed. 2007
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands
ISBN-10: 1402063431
Pagini: 620
Ilustrații: XXI, 597 p.
Dimensiuni: 155 x 235 x 33 mm
Greutate: 1.06 kg
Ediția:2nd ed. 2007
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands
Public țintă
ResearchCuprins
Genes.- Star-Recessive, a Spontaneous Mutation in Drosophila Melanogaster.- Another Case of Unequal Crossing Over in Drosophila Melanogaster.- The Relation of Repeats to Position Effect in Drosophila Melanogaster.- The pseudoallelism of white and apricot in Drosophila melanogaster.- Pseudoallelism and Gene Evolution.- The Theory and Application of a New Method of Detecting Chromosomal Rearrangements in Drosophila Melanogaster.- Some Aspects of Position Pseudoallelism.- Genes and Gene Complexes.- Genes and Development.- Genes and Developmental Pathways.- A Gene Complex Controlling Segmentation in Drosophila.- Genetic Control of Body Segment Differentiation in Drosophila.- Control of Body Segment Differentiation in Drosophila by the Bithorax Gene Complex.- Regulation of the Genes of the Bithorax Complex in Drosophila.- Molecules and Development.- Molecular Genetics of the Bithorax Complex in Drosophila Melanogaster.- The Abdominal Region of the Bithorax Complex.- Transabdominal, A Dominant Mutant of the Bithorax Complex, Produces a Sexually Dimorphic Segmental Transformation in Drosophila.- Molecular Basis of Transabdominal—A Sexually Dimorphic Mutant of the Bithorax Complex of Drosophila.- Sequence Analysis of the Cis-Regulatory Regions of the Bithorax Complex of Drosophila.- Splits in Fruitfly Hox Gene Complexes.- Evolution of the Homeobox Complex in the Diptera.- Radiation and Cancer.- Leukemia and Ionizing Radiation.- Thyroid radiation doses from fallout.- Leukemia, multiple myeloma, and aplastic anemia in american radiologists.- Ionizing Radiation and Tumor Production.- Leukemia, Radiation, and Hyperthyroidism.- Analysis of Lung Tumor Mortality in the Battelle Beagle Lifespan Experiment.- Ionizing Radiation, Cancer Induction, and Radioactive Fallout.- Historicalperspectives.- Homeosis: the first 100 years.- Remembering Sturtevant.- C. B. Bridges' Repeat Hypothesis and the Nature of the Gene.- Did Demerec Discover Intragenic Recombination in 1928?.- The Bithorax Complex: The First Fifty Years.
Recenzii
“A great book that is of interest to many geneticists, developmental biologists, and historians of science.” (Prof. Matthew P. Scott - Stanford University)
“A wonderful compendium of Lewis' papers. Lipshitz has done an outstanding job of summarizing – and in many cases clarifying – Lewis' writings.” (Prof. James F. Crow, University of Wisconsin, Madison)
“A very valuable reference for those studying developmental biology, radiation and cancer.” (Dr. Susan Celniker, Lawrence Berkeley National Laboratory, Berkeley, California)
“An excellent resource for understanding the emergence of developmental genetics.” (Prof. Siegfried Roth, University of Köln, Germany)
“Since the best way to become a good scientist is to understand how scientific ideas have been born and have developed, this book should be read by all graduate students in the areas of genetics, development and evolution.” (Prof. Markus Noll, University of Zurich, Switzerland)
“A wonderful compendium of Lewis' papers. Lipshitz has done an outstanding job of summarizing – and in many cases clarifying – Lewis' writings.” (Prof. James F. Crow, University of Wisconsin, Madison)
“A very valuable reference for those studying developmental biology, radiation and cancer.” (Dr. Susan Celniker, Lawrence Berkeley National Laboratory, Berkeley, California)
“An excellent resource for understanding the emergence of developmental genetics.” (Prof. Siegfried Roth, University of Köln, Germany)
“Since the best way to become a good scientist is to understand how scientific ideas have been born and have developed, this book should be read by all graduate students in the areas of genetics, development and evolution.” (Prof. Markus Noll, University of Zurich, Switzerland)
Caracteristici
For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume Papers are organized into sections that reflect the focus of the research Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers Provides source material for advanced undergraduate and graduate level courses in genetics, developmental biology, radiation and cancer
Descriere
Descriere de la o altă ediție sau format:
While Edward B. (‘Ed’) Lewis is famous for his contributions to genetics anddev- opmental biology y, few have read his research papers. One reason for this is availability, man ny having been published in obscure journalsor as book chapters. A second is because his papers in those ?elds are very dif?cult to read. The dif?culty derives from the fact that Lewis has published infrequently, thus manypapers are condensed reviews of man nyyears’ work presented largely in summary form rather than in detail. It is not unusual for the reader to have to infer the experimental methods, even the results, from a few sentences. Furthermore, he often presents his results in terms of abstract models; thus it can be dif?cult to separate the data from the models. Ama ajor goal of this book is to make Lewis’ keypapers accessible to researchers and students. The papers are grouped into several sections that re?ect the changing focus of his research. Each section is preceded by commentary designed to place the papers in historical perspective, with respect to Lewis’ own ideas as well as to those of the larger scienti?c community. The commentaries attempt to highlight the key methods and results—as well as the signi?cance—of each paper by explaining the science in terms that should be understandable to upper-level undergraduates, graduate students and professional researchers.
While Edward B. (‘Ed’) Lewis is famous for his contributions to genetics anddev- opmental biology y, few have read his research papers. One reason for this is availability, man ny having been published in obscure journalsor as book chapters. A second is because his papers in those ?elds are very dif?cult to read. The dif?culty derives from the fact that Lewis has published infrequently, thus manypapers are condensed reviews of man nyyears’ work presented largely in summary form rather than in detail. It is not unusual for the reader to have to infer the experimental methods, even the results, from a few sentences. Furthermore, he often presents his results in terms of abstract models; thus it can be dif?cult to separate the data from the models. Ama ajor goal of this book is to make Lewis’ keypapers accessible to researchers and students. The papers are grouped into several sections that re?ect the changing focus of his research. Each section is preceded by commentary designed to place the papers in historical perspective, with respect to Lewis’ own ideas as well as to those of the larger scienti?c community. The commentaries attempt to highlight the key methods and results—as well as the signi?cance—of each paper by explaining the science in terms that should be understandable to upper-level undergraduates, graduate students and professional researchers.