Gene Machine: The Race to Decipher the Secrets of the Ribosome
Autor Venki Ramakrishnanen Limba Engleză Hardback – 5 noi 2018
Subliniem autoritatea incontestabilă a lui Venki Ramakrishnan, laureat al Premiului Nobel, care în Gene Machine ne oferă mai mult decât o lecție de biologie moleculară: ne oferă o cronică onestă a unei curse contracronometru pentru înțelegerea ribozomului. Spre deosebire de lucrările pur tehnice, precum Structure, Function, and Genetics of Ribosomes de Boyd Hardesty, acest volum în limba engleză publicat de Oneworld Publications umanizează procesul descoperirii, expunând vulnerabilitățile și ambițiile din spatele microscopului.
Considerăm că relevanța acestui titlu rezidă în capacitatea de a explica cum „mașinăria genelor” traduce codul genetic în proteine, fundamentul vieții. Cititorii familiarizați cu The Double Helix de James D Watson vor aprecia Gene Machine pentru stilul narativ similar, dar adaptat rigorilor și complexității științei contemporane. Dacă Watson a descris structura ADN-ului, Ramakrishnan ne arată ce se întâmplă cu acea informație în laboratorul celular.
În contextul operei sale, această lucrare fundamentează temele explorate ulterior în Why We Die. Dacă în volumul despre longevitate autorul analizează declinul biologic, aici se concentrează pe motorul care susține viața. Ne-a atras atenția modul în care autorul navighează între precizia științifică și dinamica socială a comunității academice, transformând o temă de nișă într-o relatare accesibilă despre perseverență.
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Specificații
ISBN-13: 9780465093366
ISBN-10: 0465093361
Pagini: 288
Dimensiuni: 162 x 241 x 25 mm
Greutate: 0.45 kg
Ediția:1
Editura: BASIC BOOKS
Colecția Basic Books
ISBN-10: 0465093361
Pagini: 288
Dimensiuni: 162 x 241 x 25 mm
Greutate: 0.45 kg
Ediția:1
Editura: BASIC BOOKS
Colecția Basic Books
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De ce să citești această carte
Recomandăm această carte oricărui pasionat de popularizarea științei care dorește să înțeleagă nu doar „ce” s-a descoperit, ci și „cum” se ajunge la un Nobel. Cititorul câștigă o perspectivă privilegiată asupra mecanismelor moleculare ale vieții, explicată de unul dintre cei mai importanți biologi contemporani. Este un amestec rar de rigoare academică și sinceritate narativă, esențial pentru studenți și curioși deopotrivă.
Despre autor
Venki Ramakrishnan este un biolog structuralist de renume mondial, distins cu Premiul Nobel pentru Chimie în 2009 pentru studiile sale asupra structurii și funcției ribozomului. Născut în India și educat în Statele Unite, și-a desfășurat activitatea de cercetare la Laboratorul de Biologie Moleculară MRC din Cambridge. Expertiza sa în cristalografie și biofizică l-a poziționat în prima linie a cercetării genetice, fiind totodată un comunicator abil al științei, capabil să traducă procese biologice complexe pentru publicul larg.
Descriere scurtă
A
Nobel
Prize-winning
biologist
tells
the
riveting
story
of
his
race
to
discover
the
inner
workings
of
biology's
most
important
molecule
"Ramakrishnan's
writing
is
so
honest,
lucid
and
engaging
that
I
could
not
put
this
book
down
until
I
had
read
to
the
very
end."
--Siddhartha
Mukherjee,
author
ofThe
Emperor
of
All
MaladiesandThe
Gene
Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us.Gene Machineis an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end,Gene Machineis a frank insider's account of the pursuit of high-stakes science.
Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us.Gene Machineis an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end,Gene Machineis a frank insider's account of the pursuit of high-stakes science.
Notă biografică
Venki
Ramakrishnanshared
the
2009
Nobel
Prize
in
Chemistry
for
uncovering
the
structure
of
the
ribosome.
He
is
a
senior
scientist
at
the
MRC
Laboratory
of
Molecular
Biology
in
Cambridge,
UK,
and
also
the
president
of
the
Royal
Society
in
London.
Recenzii
"It
is
[Ramakrishnan's]
full
embrace
of
the
role
of
the
antihero
that
makesGene
Machineso
much
fun
to
read
and
also
serves
as
a
reminder
to
us
all
of
the
beating
human
heart
that
lies
at
the
center
of
every
advance
in
science."—Wall
Street
Journal
"An engaging and witty memoir... This profoundly human story is written with honesty and humility... This lucid and highly readable account will be enjoyed by students in any of the sciences, by those interested in the history of science, or who love reading memoirs. But really, I think that anyone who is captivated by an absorbing story well told will find much to appreciate in this fascinating book."—Forbes
"[An] absorbing account."—Scientific American
"An enchanting and invigorating work,Gene Machinecasts a many-angled light on the world of science, the nature of discovery, and on one of the deepest mysteries of twentieth-century biology. Ramakrishnan, one of the key players in deciphering the molecular basis of protein translation, gives us both a rollicking scientific story and a profoundly human tale. In the tradition ofThe Double Helix,Gene Machinedoes not hesitate to highlight the process by which science advances: moving through fits and starts, often underscored by deep rivalries and contests, occasionally pitching towards error and misconception, but ultimately advancing towards profound and powerful truths. An outsider to the world of ribosome biology--an Indian immigrant, a physicist by training--Ramakrishnan retains his 'outsider's' vision throughout the text, reminding us about the corrosive nature of scientific prizes, and the intensity of competition that drives researchers (both ideas, I suspect, will have a munificent effect on our current scientific culture).Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end."—Siddhartha Mukherjee
"The ribosome, a structure of astonishing complexity, 'lies at the crossroads of life' and Venki Ramakrishnan played a key role in revealing its biological mysteries. His superb account lays out the science with great lucidity, but he also grants us the human face of science--the hard work and brilliant insights, of course, but also the role of luck, of personalities, jealousy, money, the roulette of major awards, and the further rewards heaped upon the fortunate. Science, in his glorious telling, becomes 'a play, with good and bad characters.' Competition and collaboration can appear inseparable, crucial figures get overlooked. It's a wonderful book and a great corrective to the notion of science as dispassionate, untainted objectivity."—Ian McEwan
"The ribosome is the central processor that decodes the universal machine-code of life, and the history of its unravelling is on a par with that of DNA itself. You could think of Venki Ramakrishnan as a sort of 'nice Jim Watson.' His meticulously detailed and generous memoir has the same disarming frankness asThe Double Helix. His personal honesty about the competitive ambition that drove him is tempered by his deeply thoughtful reflections on the potentially corrupting effect of big prizes.Gene Machinewill be read and re-read as an important document in the history of science."—Richard Dawkins
"InGene Machine, [Ramakrishnan] thoughtfully embeds his trajectory in a wider meditation on how scientists make the decisions that lead to success or failure--and on how they struggle to solve complex problems... anyone who wants to know how modern science really works should read it. It's all here: the ambition, jealousy and factionalism--as well as the heroic late nights, crippling anxiety and disastrous mistakes--that underlie the apparently serene and objective surface represented by the published record."—Nature
"Gene Machineis a must-read for anyone interested in a glimpse of the messy business of how science happens."—Times(UK)
"Enlightening... one can't help celebrating with Ramakrishnan when, near his story's conclusion, the call from Stockholm arrives."—Publishers Weekly
"An enlightening and enjoyable picture of the human side of scientific research."—New York Journal of Books
"A skillful memoir... An entertaining account of a peripatetic career, academic infighting, and the colorful, charismatic, or eccentric mentors, colleagues, and competitors the author encountered as well as an often cynical view of the scientific establishment."—Kirkus Reviews
"Discovering the structure of the ribosome was a truly incredible moment in the history of humankind: this intricate, microscopic machine that lies at the heart of all life, made mostly of RNA, that mysterious material that pre-dates both DNA and protein. As its shape and moving parts came gradually into focus through ingenious applications of crystallography, it is extraordinary to think that this is a device vital to all life, yet which no living thing has seen or understood till now. In this detective story of a book, told with smiles and subtlety, Venki Ramakrishnan relates how he, an immigrant from India, managed to assemble the people, the ideas and the tools to achieve this remarkable feat, in collaboration and (sometimes sharp) competition with other scientific teams, culminating in a Nobel Prize. For students of how science actually happens, this is a book to be treasured and pored over."—Matt Ridley
"InGene Machine, one of the world's leading scientists reveals the reality of scientific discovery and the rivalry, collaboration and thrills that are involved. The result is a brilliant under-the-hood account of what it takes to win the Nobel Prize. Exciting and brutally honest, Venki's book explains the dramatic turns in the race to describe the structure of the ribosome--an essential component of every cell that has ever lived. I laughed out loud, I shouted in disbelief, and I learned so much from reading this book."—Matthew Cobb
"Quite a ride. This is a riveting personal account of the race to decipher the structure of the ribosome, one of the most complex and fundamental machines in the cell. The book takes up the baton from Watson'sDouble Helix, and like Watson, Ramakrishnan is disarmingly candid in tone, sometimes disquietingly so. His telling is laced with wisdom spun from a remarkable life story and the sharp lab anecdotes that are the lifeblood of everyday science."—Nick Lane
"This book is dynamite. Like no science book ever before, this is an honest, frank and simply jaw-dropping account of how a relative outsider ended up winning a Nobel Prize."—Daniel M. Davis
"An engaging and witty memoir... This profoundly human story is written with honesty and humility... This lucid and highly readable account will be enjoyed by students in any of the sciences, by those interested in the history of science, or who love reading memoirs. But really, I think that anyone who is captivated by an absorbing story well told will find much to appreciate in this fascinating book."—Forbes
"[An] absorbing account."—Scientific American
"An enchanting and invigorating work,Gene Machinecasts a many-angled light on the world of science, the nature of discovery, and on one of the deepest mysteries of twentieth-century biology. Ramakrishnan, one of the key players in deciphering the molecular basis of protein translation, gives us both a rollicking scientific story and a profoundly human tale. In the tradition ofThe Double Helix,Gene Machinedoes not hesitate to highlight the process by which science advances: moving through fits and starts, often underscored by deep rivalries and contests, occasionally pitching towards error and misconception, but ultimately advancing towards profound and powerful truths. An outsider to the world of ribosome biology--an Indian immigrant, a physicist by training--Ramakrishnan retains his 'outsider's' vision throughout the text, reminding us about the corrosive nature of scientific prizes, and the intensity of competition that drives researchers (both ideas, I suspect, will have a munificent effect on our current scientific culture).Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end."—Siddhartha Mukherjee
"If
someone
had
told
me
that
one
of
the
most
witty
and
enthralling
books
I'd
read
this
year
would
be
on
the
quest
to
understand
ribosomes,
I
believe
I
would
have
laughed
in
his
face,
but
I
would
have
been
quite
wrong.Gene
Machineis
beyond
superb."
—Bill
Bryson"The ribosome, a structure of astonishing complexity, 'lies at the crossroads of life' and Venki Ramakrishnan played a key role in revealing its biological mysteries. His superb account lays out the science with great lucidity, but he also grants us the human face of science--the hard work and brilliant insights, of course, but also the role of luck, of personalities, jealousy, money, the roulette of major awards, and the further rewards heaped upon the fortunate. Science, in his glorious telling, becomes 'a play, with good and bad characters.' Competition and collaboration can appear inseparable, crucial figures get overlooked. It's a wonderful book and a great corrective to the notion of science as dispassionate, untainted objectivity."—Ian McEwan
"The ribosome is the central processor that decodes the universal machine-code of life, and the history of its unravelling is on a par with that of DNA itself. You could think of Venki Ramakrishnan as a sort of 'nice Jim Watson.' His meticulously detailed and generous memoir has the same disarming frankness asThe Double Helix. His personal honesty about the competitive ambition that drove him is tempered by his deeply thoughtful reflections on the potentially corrupting effect of big prizes.Gene Machinewill be read and re-read as an important document in the history of science."—Richard Dawkins
"InGene Machine, [Ramakrishnan] thoughtfully embeds his trajectory in a wider meditation on how scientists make the decisions that lead to success or failure--and on how they struggle to solve complex problems... anyone who wants to know how modern science really works should read it. It's all here: the ambition, jealousy and factionalism--as well as the heroic late nights, crippling anxiety and disastrous mistakes--that underlie the apparently serene and objective surface represented by the published record."—Nature
"Gene Machineis a must-read for anyone interested in a glimpse of the messy business of how science happens."—Times(UK)
"Enlightening... one can't help celebrating with Ramakrishnan when, near his story's conclusion, the call from Stockholm arrives."—Publishers Weekly
"An enlightening and enjoyable picture of the human side of scientific research."—New York Journal of Books
"A skillful memoir... An entertaining account of a peripatetic career, academic infighting, and the colorful, charismatic, or eccentric mentors, colleagues, and competitors the author encountered as well as an often cynical view of the scientific establishment."—Kirkus Reviews
"Discovering the structure of the ribosome was a truly incredible moment in the history of humankind: this intricate, microscopic machine that lies at the heart of all life, made mostly of RNA, that mysterious material that pre-dates both DNA and protein. As its shape and moving parts came gradually into focus through ingenious applications of crystallography, it is extraordinary to think that this is a device vital to all life, yet which no living thing has seen or understood till now. In this detective story of a book, told with smiles and subtlety, Venki Ramakrishnan relates how he, an immigrant from India, managed to assemble the people, the ideas and the tools to achieve this remarkable feat, in collaboration and (sometimes sharp) competition with other scientific teams, culminating in a Nobel Prize. For students of how science actually happens, this is a book to be treasured and pored over."—Matt Ridley
"This
exhilarating
account
of
the
race
to
understand
the
molecular
machine
that
turns
genes
into
flesh
and
blood
is
remarkable
for
its
candid
insights
into
the
way
science
is
really
done,
by
human
beings
with
all
their
talents
and
foibles.
Venki
Ramakrishnan,
an
outsider
in
the
race,
gives
an
insider's
view
of
the
decades-long
quest
to
map
the
million
atoms
in
the
machine
to
fathom
the
fundamentals
of
life,
pave
the
way
for
new
antibiotics,
and
share
the
glory
of
the
Nobel
prize."
—Roger
Highfield"InGene Machine, one of the world's leading scientists reveals the reality of scientific discovery and the rivalry, collaboration and thrills that are involved. The result is a brilliant under-the-hood account of what it takes to win the Nobel Prize. Exciting and brutally honest, Venki's book explains the dramatic turns in the race to describe the structure of the ribosome--an essential component of every cell that has ever lived. I laughed out loud, I shouted in disbelief, and I learned so much from reading this book."—Matthew Cobb
"Quite a ride. This is a riveting personal account of the race to decipher the structure of the ribosome, one of the most complex and fundamental machines in the cell. The book takes up the baton from Watson'sDouble Helix, and like Watson, Ramakrishnan is disarmingly candid in tone, sometimes disquietingly so. His telling is laced with wisdom spun from a remarkable life story and the sharp lab anecdotes that are the lifeblood of everyday science."—Nick Lane
"This book is dynamite. Like no science book ever before, this is an honest, frank and simply jaw-dropping account of how a relative outsider ended up winning a Nobel Prize."—Daniel M. Davis
Descriere
Descriere de la o altă ediție sau format:
The thrilling story of how scientists unlocked a new window onto how life works
The thrilling story of how scientists unlocked a new window onto how life works