TThis report presents the results of a Substance Abuse Program and Methods of Evaluation study conducted by the Volpe National Transportation Systems Center in fiscal year 2000. The study determines the progress of the Drug and Alcohol Compliance Program in meeting U.S. Department of Transportation and Federal Transit Administration (FTA) strategic goals and objectives. The analysis also allows the FTA to determine whether the current program is operating effectively and efficiently while providing options for allowing limited resources to optimize results. Utilizing 5 years of data and 7 years of experience administering the program, the assessment demonstrates the effectiveness of the FTA Drug and Alcohol program and the ability of transit agencies to contribute significant economic benefits to both industry and society as a whole by effectively enforcing the regulations.