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From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors de Christopher J. Langmead

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors: Advances in Pharmacology, cartea 88

Christopher J. Langmead
en Limba Engleză Hardback – 8 mai 2020
From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.


  • Includes the authority and expertise of leading contributors in pharmacology
  • Presents the latest release in the Advances in Pharmacology series
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Specificații

ISBN-13: 9780128201879
ISBN-10: 0128201878
Pagini: 328
Dimensiuni: 152 x 229 mm
Greutate: 0.61 kg
Editura: ELSEVIER SCIENCE
Seria Advances in Pharmacology

Public țintă

investigators in neuroscience, pharmacology, neurology, psychiatry, medicine.

Cuprins

    1. The computational modeling of allosteric modulation of metabotropic glutamate receptorsLaura Pérez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary Tresadern
    2. Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulatorsKirstie A. Bennett, John A. Christopher and Benjamin G. Tehan
    3. The function and allosteric control of the human sweet taste receptorGuy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole Servant
    4. The different aspects of the GABAB receptor allosteric modulationJulie Kniazeff
    5. RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptorsAugen A. Pioszak and Debbie L. Hay
    6. Strategies and considerations of G-protein-coupled receptor photopharmacologyAlice E. Berizzi and Cyril Goudet
    7. Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacologyFrancis S. Willard, Joseph D. Ho and Kyle W. Sloop
    8. Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigationsKari A. Johnson and David M. Lovinger
    9. Allosteric modulation of muscarinic receptors in alcohol and substance use disordersLeigh C. Walker and Andrew J. Lawrence
    10. M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?
Miriam Scarpa, Sarah Hesse and Sophie J. Bradley