In better days, the elegant young dog Francine enjoyed wealth and privilege. Now she spends the hours staring at her friends through the grim bars of a cage. Her terrier pal Sammie, her cousin Flitz, and her three hound buddies pace their cages with increasing desperation. Francine comes from noble lines, and the courage of her ancestors runs in her veins. But the days to come will demand every ounce of cleverness, courage, and grit within her. Even if she escapes with her friends, a hostile world awaits them. They will have to look long and hard to find people with hearts big enough to befriend six homeless dogs.
But a man with a scalpel and no conscience has prepared a room for Francine and her friends. He takes Flitz away to begin a painful journey that will end in her death unless Francine finds a way out. Time is running short and soon he will come for Francine.