Francine travels over four thousand miles from her family and best friends: Petta, Jessica, Georgina and Alysia from Philadelphia, Pennsylvania to Munich, Germany to accept a job offer with new responsibilities as a genetics research department manager. The offer alone proves her nickname "Miss Smarty Pants" is perfect for her. With new best friends, Francine transitions into German social life and activities but while falling in love, Francine becomes the number one suspect in a serious crime.