Developing countries are following developed countries in entering IT into different aspects of their lives. Although they can use the experiences of developed countries in facing similar challenges in utilizing new technologies, because of some differences such as culture, infrastructure, and so on; they have to find the importance of different variables which can affect desired outcomes. This book is an attempt to gain an understanding of how a developing country (Iran) is coping with these challenges while implementing E-learning in its schools. It determines seven most important factors and their importance using statistical methods. Afterward, the role of different readiness factors in using E-learning is evaluated. The findings will be helpful for both academics and practitioners of E-Learning systems especially in developing countries.