Run-Off-Road crashes cause a large proportion of fatalities and serious injuries to the vehicle occupants. In this study, fatal crashes from the Fatality Analysis Reporting System for passenger vehicles (passenger cars and LTVs) during the period 1991 to 2007 wre used to identify the roadway- (e.g., rural/urban nature and curve existence), driver- (e.g., age, gender, drowsy, and alcohol use), environmental- (e.g., weather, lighting condition), and vehicle-related factors (e.g., speeding) associated with the fatal single vehicle run-off-road crashes.