Shortly before the U.S. invasion of Iraq in 2003, psychotherapist Rash and his girlfriend Kayla, fearing a biological attack on the U.S. by Islamic terrorists, flee from vulnerable Ann Arbor, Michigan, to the presumed safety of Oak, a small rural town in eastern Ohio. While there the couple attempts to resolve problems in their testy relationship, but this is complicated by a local militia leader who tries to recruit Rash. The leader also recruits an expert to create a lethal virus that will target specific ethnic groups, but it turns out that the expert has a grievance-driven agenda of his own.