This book constitutes the refereed post-conference proceedings of the 2nd International Conference on Edge Computing and IoT, ICECI 2021, held in December 2021 in Shenzhen, China. Due to COVID-19 pandemic the conference was held virtually. The explosion of the big data generated by ubiquitous edge devices motivates the emergence of applying machine learning systems for edge computing and Internet of Things (IoT) services. Machine learning techniques are delivering a promising solution to the industry for building IoT systems and to make innovation at a rapid pace. The 12 full papers of ICECI 2021 were selected from 26 submissions and present results and ideas in the area of edge computing and IoT.