Heavy ion reaction is a fast growing subject of nuclear physics. Heavy ions are the nuclei equal to or heavier than the alpha-particle. In this book, heavy ion reactions study within the dynamical cluster-decay model (DCM) and its simplified version ℓ-summed extended-Wong model of Gupta and collaborators, with deformation and orientations effects included and nuclear proximity potential derived from semi-classical extended Thomas Fermi model based on Skyrme energy density formalism, from different mass regions of Periodic Table are presented. The main aim of this work is to examine the fusion hindrance phenomenon via the modification of barrier in terms of ℓ, orientations of nuclei, the defining parameters of the Fermi density, or the Skyrme force parameters themselves. This book further advances the dynamics of heavy ion reaction. This work will be of interest to the nuclear physicists all over the globe.