Human body has the natural ability to protect and heal itself, like all the systems which existing in the nature. It means that, Immune System which is one of the main systems in humans that protects them from illness. In other words, it is a network of cells, tissues, and organs designed complexly for preventing the body against germs, viruses, and other form of body toxins. As microbial invasions attempt to pass through the body's natural barriers, immune system alerts body's defenses and calls to action the natural processes that keep the body safe and healthy.On the other hand, Risk Management in the organizations includes the processes concerned with identifying, analyzing and evaluation the factors that might adversely affect project outcomes which is important as one of the main items in security management. Because of these many methodologies are created for risk management, but some failures are specified in these methodologies. In other words, they are not complete. Hence the research wants to find a relationship between Immune System as one of the complete management systems in nature and current methodologies of risk management, by comparison of them with each other.