Provides an up-to-date survey of the clinical, educational, developmental, psychosocial, and vocational issues relevant to people with Down syndrome. * Discusses implications of the Human Genome Project and sequencing of chromosome 21. * Incorporates newest developments concerning issues of sexuality, inclusion, self-advocacy, transition into adulthood, and legislation. * Covers recent updates to the "Health Care Guidelines for Individuals with Down Syndrome." * Includes debated, controversial topics of alternative and non-conventional therapies.