Developments in Statistical Evaluation of Clinical Trials
Editat de Kees van Montfort, Johan Oud, Wendimagegn Ghideyen Limba Engleză Hardback – 27 oct 2014
Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.
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Specificații
ISBN-13: 9783642553448
ISBN-10: 3642553443
Pagini: 376
Ilustrații: XI, 361 p. 61 illus.
Dimensiuni: 160 x 241 x 26 mm
Greutate: 0.73 kg
Ediția:2014
Editura: Springer
Locul publicării:Berlin, Heidelberg, Germany
ISBN-10: 3642553443
Pagini: 376
Ilustrații: XI, 361 p. 61 illus.
Dimensiuni: 160 x 241 x 26 mm
Greutate: 0.73 kg
Ediția:2014
Editura: Springer
Locul publicării:Berlin, Heidelberg, Germany
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Public țintă
ResearchCuprins
Preface.- List of contributors.- 1.Statistical Models and Methods for Incomplete Data in Randomized Clinical Trials. M.A. McIsaac and R.J. Cook.- 2.Bayesian Decision Theory and the Design and Analysis of Randomized Clinical Trials. A.R. Willan.- 3.Designing Multi-Arm Multi-Stage Clinical Studies. T.Jaki.- 4.Statistical Approaches to Improving Trial Efficiency and Conduct. J.Pogue, P. J. Devereaux and S.Yusuf.- 5.Competing Risk and Survival Analysis. K.van Montfort, P.Fennema and W.Ghidey.- 6.Recent Developments in Group-Sequential Designs. J.M. S. Wason.- 7.Statistical Inference for Non-Inferiority of a Diagnostic Procedure Compared to an Alternative Procedure, Based on the Difference in Correlated Proportions from Multiple Raters. H.Saeki and T.Tango.- 8.Design and Analysis of Clinical Trial Simulations. K.Kuribayashi.- 9.Causal Effect Estimation and Dose Adjustment in Exposure-Response Relationship Analysis. J.Wang.- 10.Different Methods to Analyse Results of a Randomised Controlled Trial with More Than one Follow-up Measurement. J.W. R. Twisk.- 11.Statistical Methods for the Assessment of Clinical Relevance. M.Kieser.- 12.Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses. R.J. Cook and K.-A.Lee.- 13.Statistical Validation of Surrogate Markers in Clinical Trials. A.Alonso, G.Molenberghs and G.van Breukelen.- 14.Biomarker-Based Designs of Phase III Clinical Trials for Personalized Medicine. S.Matsui, T.Nonaka and Y.Choai.- 15.Dose-Finding Models for Two-Agent Combination Phase I Trials. A.Hirakawa and S.Matsui.- 16.Multi-State Models Used in Oncology Trials. B.Gaschler-Markefski, K.Schiefele, J.Hocke and F.Fleischer.- 17.Review of Designs for Accommodating Patients’ or Physicians’ Preferences in Randomized Controlled Trials. A.S. Ismaila and S.D. Walter.- 18.Dose Finding Methods in Oncology: From the Maximum Tolerated Dose to the Recommended Phase II Dose. X.Paoletti and A.Doussau.
Textul de pe ultima copertă
This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials.
Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.
Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.
Caracteristici
Provides an overview of important statistical methods used in clinical trials Chapters supplemented with a discussion of practical applications Up-to-date reference for researchers and practitioners involved with clinical trials