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CPP, Cell-Penetrating Peptides

Autor Ülo Langel
en Limba Engleză Paperback – 14 aug 2020
In this book, a summary and update of the most important areas of CPP research are presented, whilst  raising relevant questions for further development. 
The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo are discussed. Therapeutic potential of CPPs and commercial developments are discussed. 
The monograph is written for researchers and students in the field.

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Specificații

ISBN-13: 9789811387494
ISBN-10: 9811387494
Pagini: 470
Ilustrații: XII, 470 p. 25 illus., 17 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.67 kg
Ediția:1st ed. 2019
Editura: Springer Nature Singapore
Colecția Springer
Locul publicării:Singapore, Singapore

Cuprins

Classes and applications of CPP.- CPP functionalization.- Protein delivery and mimicry.- Targeting strategies.- Methods for detection and visualization of CPPs.- Methods for structural studies of CPPs.- Kinetics.- Toxicity and immune response.- Cell-translocation mechanisms of CPPs.- Clinical trials and commercialization using CPPs.- Therapeutic potential of CPPs.

Textul de pe ultima copertă

In this book, a summary and update of the most important areas of CPP research are presented, whilst  raising relevant questions for further development. 
The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo are discussed. Therapeutic potential of CPPs and commercial developments are discussed. 
The monograph is written for researchers and students in the field.

Caracteristici

Provides a comprehensive update of cell penetrating peptides (CPP) Summarizes the CPP uptake mechanisms and their critical analysis Shows methods used for CPP studies and applications

Descriere

Descriere de la o altă ediție sau format:
In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development.

Notă biografică

Ülo Langel is a Professor Emeritus at the Department of Biochemistry and Biophysics, Stockholm University, and at the Institute of Technology, Tartu University. Prof. Langel graduated from Tartu University, Tartu, Estonia, as bioorganic chemist in 1974; he has received his PhD degree twice: in 1980 from Tartu University, Tartu, Estonia (bioorganic chemistry), and in 1993 from Tartu University/Stockholm University (biochemistry/neurochemistry). His professional experience includes a career at Tartu University, Tartu, Estonia (from junior research fellow to Associate Professor, Visiting Professor, and Professor 1974-now); The Scripps Research Institute, La Jolla, CA, USA (Associate Professor, and Adjunct Professor 2000-now); and Stockholm University (from research fellow to Associate Professor, Professor and Chairman, 1987-now). He is a Honorary Professor at Ljubljana University, Slovenia. He was a Chairman of the Board of small companies Pepfex (Stockholm) and Cepep (Estonia) and member of the Board of Orexo (Sweden). In 2013 he was elected a member of Academia Europaea and in 2015, a foreign member of the Estonian Academy of Sciences.  
Prof. Langel has been selected as a Fellow Member of International Neuropeptide Society (1995), and is a member of International Society for Neurochemistry, European Peptide Society, Swedish Biochemical Society and Estonian Biochemical Society.  He has been awarded a White Star Order, 4th class, by Estonian Republic. He has been invited lecturer at numerous international conferences, and is a coauthor of more than 480 scientific articles and 20 approved or pending patents. His research interest is in neurochemistry where his research is aimed to study peptides, particularly neuropeptide receptors, and in drug delivery by cell-penetrating peptides