COX-2 Inhibitors (Milestones in Drug Therapy) de Joanne Van Ryn

COX-2 Inhibitors: Milestones in Drug Therapy

Joanne Van Ryn

Michel Pairet

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.

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Cuprins

The discovery of COX-2.- Structural diversity of selective COX-2 inhibitors.- The molecular and biological basis for COX-2 selectivity.- Pharmacology and toxicology of COX-2 inhibitors.- Efficacy and gastrointestinal safety of selective COX-2 inhibitors.- Role of COX-2 in ulcers and ulcer healing.- COX-2 and the cardiovascular system.- Effects on the kidney: role of COX-2 inhibitors.- Effects on the lungs: role of COX-2 inhibitors.- Reproduction: role of COX-2 and its inhibition.- COX-2 in cancer.

Caracteristici

GIVES BACKGROUND INFORMATION ABOUT THE DISCOVERY OF COX-2 PROVIDES AN EXCELLENT OVERVIEW OF THE PHARMACOLOGY AND TOXICOLOGY OF COX-2 AGENTS PROVIDES INFORMATION ABOUT EFFECTS OF COX-2 ON THE CARDIOVASCULAR SYSTEM, LUNGS, KIDNEY, ULCERS AND REPRODUCTION TARGETS MAJOR BIOLOGICAL SYSTEMS WHERE COX-2 INHIBITORS HAVE THE POTENTIAL TO BE DIFFERENT FROM NON-SELECTIVE INHIBITORS AND REVIEWS EVIDENCE FOR AND AGAINST THIS Includes supplementary material: sn.pub/extras