In this issue of Nursing Clinics of North America, guest editor and Director of the COVID-19 Operations Control Center at Penn State College of Nursing Dr. Kelly A. Wolgast brings her considerable expertise to the topic of COVID-19 and Pandemic Preparedness: Lessons Learned and Next Steps Nurses have had to adapt and innovate in the clinical, leadership, technology, research, and academic environments to withstand the impacts of COVID-19, all while innovating new strategies to ensure that quality patient care remains the priority. This issue reflects the work and outcomes that stemmed from necessity by nurses and other health care partners to respond to the needs of patients during this extraordinary and challenging time in history.