In this issue of Pediatric Clinics of North America, guest editor Dr. Michael R. DeBaun brings his considerable expertise to the topic of A Primer for Pediatric Clinicians: Management of Acute and Ongoing Sickle Cell Disease. As the responsibility for primary and secondary care of children with SCD is increasingly being shifted to general pediatricians, this issue has been developed to support pediatric clinicians in this role. Top experts provide essential pediatric care principles and management strategies for integrating SCD care into the routine practice of a busy pediatric clinician's office, ensuring that children with SCD receive the comprehensive care they need in a medical home setting.