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Cell-Penetrating Peptides de Ülo Langel

Cell-Penetrating Peptides

Editat de Ülo Langel
en Limba Engleză Hardback – 24 iul 2015
Divided into three parts this volume summarizes the most important areas of Cell-Penetrating Peptides (CPP) research . Part one briefly presents the historical background of CPP studies and the classifications of the available CPPs, and then summarizes the approaches for prediction of novel CPPs. Part two mainly describes the methods for studies of “naked” CPPs, that is, CPPs without conjugated cargos. Last but not least part three presents a representative and brief summary of functionality issues of CPPs, both in vitro and in vivo. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.
Concise and easy-to-use, Cell-Penetrating Peptides: Methods and Protocols, Second Edition hopes to raise relevant questions for further development.
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Specificații

ISBN-13: 9781493928057
ISBN-10: 1493928058
Pagini: 492
Ilustrații: XVI, 472 p. 73 illus., 45 illus. in color.
Dimensiuni: 183 x 260 x 31 mm
Greutate: 1.23 kg
Ediția:2nd edition 2015
Editura: Springer
Locul publicării:New York, NY, United States

Public țintă

Professional/practitioner

Cuprins

Classes of Cell-Penetrating Peptides.- Penetratin Story: An Overview.- Prediction of Cell-Penetrating Peptides.- Computer-Aided Virtual Screening and Designing Of Cell-Penetrating Peptides.- Investigating Membrane Interactions and Structures Of Cpps.- Determining the Effects Of Membrane-Interacting Peptides on Membrane Integrity.- Study of CPP Mechanisms By Mass-Spectrometry.- Methods to Study the Role of the Glycocalyx in the Uptake of Cell Penetrating Peptides.- Toxicity, Immunogenicity, Uptake and Kinetics Methods for Cpps.- Unravelling the Mechanisms Of Peptide-Mediated Delivery of Nucleic Acids Using Electron Microscopy.- SCARA Involvement in the Uptake of Nanoparticles Formed by Cell Penetrating Peptides.- Protein Mimicry and the Design of Bioactive Cell Penetrating Peptides.- Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics.- Identification and Characterization of Homing Peptides Using In Vivo Peptide Phage Display.- Antiviral and Antimicrobial Applications Of Cell Penetrating Peptides.- Visualising Actin Architectures in Cells Incubated with Cell Penetrating Peptides.- Cell-Penetrating Peptides as Carriers For Transepithelial Drug Delivery In Vitro.- A Pathway Toward Tumor Cell Selective Cpps?.- Characterization of Cellular Internalization Pathways for CPP-Mediated Oligonucleotide Delivery Pepfects and Nickfects.- In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy.- Applications of Apob LDLR Binding Domain Approach for the Development of CNS Penetrating Peptides for Alzheimer’s Disease.-Utilization of Cpps for In Vivo Delivery of Bioactive Cargo - The Effect Of Cargo Type, CPP-Cargo Association Method and Formulation.- Application of Cpps for Brain Delivery.- Intracellular Delivery of Nanoparticles with Cell Penetrating Peptides.- Multifunctional Oligoaminoamides for The Receptor-Specific Delivery of Therapeutic RNA.- Cell Penetrating Peptides for Chemical Biological Studies.- Experiences with CPP-Based Self Assembling Peptide Systems for Topical Delivery of Botulinum Toxin.- Applications of Cpps in Gene Modulation of Plants.- DNA Transfer Into Animal Cells Using Stearyled CPP Based Transfection Reagent.- Live Cell Genomics: Cell-Specific Transcriptome Capture in Live Tissues and Cells.- Live Cell Genomics:  RNA Exon-Specific RNA Binding Protein Isolation.

Textul de pe ultima copertă

Divided into three parts this volume summarizes the most important areas of Cell-Penetrating Peptides (CPP) research . Part one  briefly presents the historical background of CPP studies and the classifications of the available CPPs, and then summarizes the approaches for prediction of novel CPPs. Part two mainly describes the methods for studies of “naked” CPPs, that is, CPPs without conjugated cargos. Last but not least part three presents a representative and brief summary of functionality issues of CPPs, both in vitro and in vivo. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.
 Concise and easy-to-use, Cell-Penetrating Peptides: Methods and Protocols, Second Edition hopes to raise relevant questions for further development. 

Caracteristici

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Recenzii

From the reviews:
“Prof. Ulo Langel … rightly explain in a necessary preface that there are in use so many definition for the same things: protein transduction domain (PTDs), Trojan peptides, model amphipathic peptides (MAPs), membrane translocating sequences (MTS) that the best way to refer to all of these molecules is to call all of them cell-penetrating peptides, CPPs. … Clearly enough, the cell-penetrating peptides volume is surely of great help for basic research and for clinicians engaged in translational medicine.” (Carlo Alberto Redi, European Journal of Histochemistry, Vol. 55, 2011)