Bladder Disease de Anthony Atala

Bladder Disease: Research Concepts and Clinical Applications: Advances in Experimental Medicine and Biology, cartea 539

Anthony Atala

Debra Slade

In 1996, the National Bladder Foundation (NBF) was founded by a dedicated group of physicians and researchers propeIled by the urgent need to find better treatments for bladder disease. Committed to increasing bladder disease research and to supporting its research community, the NBF coordinates and sponsors the International Bladder Symposium (IBS) in Washington, DC. Now considered to be a premier scientific assembly, the IBS brings together international leaders in bladder disease research to present and discuss their findings. It is the only international conference where all areas of bladder disease research are exclusively covered and where bladder disease researchers are provided with a unique opportunity to share their results and theories. IBS participants contributed the research papers included in this publication in 2000 and 2001. AIl substantial areas of bladder disease research are addressed, including oncology and ceIlular biology, neurophysiology, neurogenic bladder andincontinence, immunology, inflammation and infection, muscle, matrix and obstruction, and new frontiers and therapies of the bladder. Assembled in one publication, these papers and their findings demonstrate the high scientific caliber of the dedicated researchers in this field and the potential for significant discoveries in treatment options in the next decade.

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Cuprins

Oncology and Cellular Biology.- 1. Recent Developments in the Treatment of Bladder Cancer.- 2. Interferon-? Response and Signal Transduction Pathway in Transitional Carcinoma Cell Lines.- 3. Molecular Cloning and Expression of Uroplakins in Transitional Cell Carcinoma.- 4. Application of a Novel Protein Chip Mass Spectrometry Technology for the Identification of Bladder Cancer-Associated Biomarkers.- 5. The Photodynamic Diagnosis (PDD) for Early Detection of Carcinoma and Dysplasia of the Bladder.- 6. Prediction of Lymph Node Metastasis Based on P53 and nm23-Hl Expression in Muscle Invasive Grade III Transitional Cell Carcinoma of Bladder.- 7. Detection of HER-2/neuCEP 17 Mutations at Invasive Bladder Cancer.- 8. Ki67, P53, nm23, and DNA Cytometry in Bladder Cancer: Potential Markers for Detection of Recurrence.- 9. Comparison of Cytology and Nuclear Matrix Protein 22 (NMP 22) for the Detection and Follow-Up of Bladder Cancer.- 10. The Effect of Contrast Material on Transitional Cell Carcinoma Viability.- 11. Fluorodeoxyglucose Positron Emission Tomography Studies in the Diagnosis and Staging of Transitional Cell Carcinoma.- 12. Radiochemotherapy in Locally Invasive Non-Metastatic Carcinoma of the Bladder.- 13. Gene and Antisense Therapy of Bladder Cancer.- 14. Tumor Suppressor Genes of Bladder Cancer and Potential for Gene Therapy.- Muscle, Matrix, and Obstruction.- 15. Molecular Response of the Bladder to Obstruction.- 16. The Role of Lipids and Lipid Metabolites in Urinary Bladder Dysfunction Induced by Partial Outlet Obstruction.- 17. Intercellular Communication and Bladder Function.- 18. Ischemia as an Etiological Factor in Bladder Instability: Implications for Therapy.- 19. Effect of Chronic Ischemia on Bladder Structure and Function.- 20. Ultrastructural Diagnosis of Neuropathic Detrusor Overactivity: Validation of a Common Myogenic Mechanism.- 21. Serial Changes of Smooth Muscle Cell Phenotypes in Rat Urinary Bladder Following Partial Outflow Obstruction.- 22. Study of Detrusor Dysfunction Due to Outlet Obstruction: Link Between Analysis of Uroflows of Men with Benign Prostatic Hyperplasia and Animal Studies.- 23. Ultrasonic Measurement of Bladder Weight as a Novel Urodynamic Modality.- Neurophysiology, Neurogenic Bladder, and Incontinence.- 24. Experimental Neurogenic Cystitis.- 25. Murine In Vitro Whole Bladder Physiology.- 26. Ca2+ Sparks and KCa Channels: Novel Mechanisms to Relax Urinary Bladder Smooth Muscle.- 27. The Effect of Intravesical Capsaicin and Resiniferatoxin in Neurogenic Bladder Dysfunction.- 28. On the Physioanatomy of Micturition and Urinary Continence-New Concepts.- 29. Stress Urinary Incontinence: New Concept of Pathogenesis and Treatment by Pudendal Canal Decompression.- 30. Transcutaneous Electrovesicogram in Normal Volunteers and Patients with Interstitial Cystitis, Neurogenic Bladder, Benign Prostatic Hyperplasia, and after Cystectomy.- 31. Extracorporeal Electromagnetic Stimulation for Urinary Incontinence andBladder Disease.- 32. Pubovaginal Sling Surgery without Using Abdominal Leak Point Pressure: An Outcomes Analysis.- 33. The Use of Synthetic Materials in Pubovaginal Sling.- 34. Surgical Implantation of the Synthetic Sling (The 6-Point Fixation Technique and Weight-Adjusted Spacing Nomogram): Technique and Results.- 35. Reconstructive Surgery in Neuropathic Bladder.- 36. The Role of the Simple Cystectomy in Urologic Surgery.- Immunology, Inflammation, and Infection.- 37. Neurogenic Inflammation of the Bladder.- 38. Urine-Induced Apoptosis in Cultured Bladder Urothelial Cells.- 39. Bacillus of Calmette and Guerin Modulates Nuclear Factor Kappa ? in Two Urothelial Carcinoma Cell Lines.- 40. Induction of Urothelial Cell Proliferation by Fibroblast Growth Factor-7 in RAG 1-Deficient Mice.- 41. Development of a Recombinant FimCH Vaccine for Urinary Tract Infections.- 42. Intravesicular Pain Mapping.- 43. A Hypothesis for the Etiology of Interstitial Cystitis.- 44. Pentosanpolysulfate (Elmiron) is a Potent Inhibitor of Mast Cell Histamine Secretion.- 45. The Efficacy of Intravesicular Sterile Sodium Chondroitin Sulfate 0.2% in Potassium Tested Positive Patients with Interstitial Cystitis.- 46. Cystectomy Causes Immunosuppression in Bladder Cancer.- New Frontiers and Therapies.- 47. Nocturia.- 48. The Fate of Urinary Bladder Smooth Muscle after Outlet Obstruction—A Role for the Sarcoplasmic Reticulum.- 49. Alteration of Collagen Three-Dimensional Architecture in Noncompliant Human Urinary Bladder.- 50. Modulation of Angiogenesis: Experimental Strategies and Potential Therapeutic Applications.- 51. Methods of Testing Urethral Resistance in the Female Rat.- 52. Virtual Reality Surgical Simulation for Lower Urinary Tract Endourologic Surgery.- 53. Autologous Muscle Transfer for Reconstruction of the Lower Urinary Tract.- 54. Effectiveness of Denuding the Intestinal Mucosa by Submucosal Injection in the Porcine Model.- 55. Urinary Diversion in the Management of Chronic Perineal Skin Ulceration in Spinal Cord Injured Patients Following Sphincterotomy.- 56. The Artificial Urinary Bladder.- 57. Comparison of the Breaking Strength of Polyglactin Mesh in Urine, Serum, and Cell Culture Media.- 58. Growth of Cultured Human Urothelial Cells Into Stratified Urothelial Sheet Suitable for Autografts.- 59. Future Perspectives in Bladder Reconstruction.