Emotions are dangerous, which is why the graduates of Moscow's famed spy school the Red Room are taught to keep their enemies close and their loved ones at a distance. Black Widow and Red Widow, also known as Natasha Romanoff and Ava Orlova, forgot that lesson once, and they won't forget it again. Once again, nothing is as it seems, no one can be trusted, and no one is safe - not unless the Widows can stop a conspiracy involving stolen nuclear warheads, mind-altering chemical weapons, and ultimately, betrayal by old friends and enemies alike.