Bacteria and Intracellularity (ASM Books)

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en Limba Engleză Hardback – 05 Mar 2020

Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria.

This book offers a wide-ranging look at the latest studies, including:

  • foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota
  • infections of the urogenital tract, endothelial barriers, and the nervous system
  • major advances in work with Mycobacterium tuberculosis and M. leprae
  • subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs
  • endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens
  • research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity
  • the latest developments in technology, for the next steps in the study of intracellularity

All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.

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ISBN-13: 9781683670254
ISBN-10: 1683670256
Pagini: 384
Dimensiuni: 222 x 273 x 22 mm
Greutate: 1.29 kg
Editura: Wiley
Seria ASM Books

Locul publicării: Hoboken, United States

Notă biografică

Pascale Cossart is considered a pioneer in cellular microbiology. Her research has led to new concepts in infection biology as well as in cell biology and fundamental microbiology, including RNA-mediated regulation. Her contributions have been recognized by several international awards and election to several academies, including the National Academy of Sciences and the National Academy of Medicine, and in January 2016 she was named Secrétaire Perpétuel de l'Académie des Sciences, Paris.

Craig R. Roy trained in the laboratory of Stanley Falkow at Stanford University and in the laboratory of Ralph Isberg at Tufts University, and is currently Waldemar Von Zedtwitz Professor of Microbial Pathogenesis and Immunobiology at Yale University. His laboratory uses multidisciplinary approaches to elucidate the mechanisms employed by intracellular pathogens to modulate vesicular transport and the host immune response.

Philippe Sansonetti is professor and head of the Unité de Pathogénie Microbienne Moléculaire at Institut Pasteur in Paris and chair of Microbiology and Infectious Diseases at the Collège de France. Professor Sansonetti is a member of the French Academy of Science, the National Academy of Sciences, and the Royal Society. His investigations concern the pathogenesis of enteric infections, particularly Shigella, including vaccine development and the molecular cross-talk between microbiota and the gut epithelium.


Contributors ix

Preface xv

About the Editors xvii

I. Cellular microbiology in the study of tissue and organ infections

1. Interaction between Intracellular Bacterial Pathogens and Host Cell Mitochondria 3
Anna Spier, Fabrizia Stavru, and Pascale Cossart

2 Shigella Pathogenesis: New Insights through Advanced Methodologies 15
Pamela Schnupf and Philippe J. Sansonetti

3. The Interplay between Salmonella enterica Serovar Typhimurium and the Intestinal Mucosa during Oral Infection 41
Annika Hausmann and Wolf-Dietrich Hardt

4. New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems 59
Alyssa C. Fasciano, Joan Mecsas, and Ralph R. Isberg

5. The Many Faces of Bacterium-Endothelium Interactions during Systemic Infections 69
Dorian Obino and Guillaume Duménil

6. Reaching the End of the Line: Urinary Tract Infections 83
Kevin O. Tamadonfar, Natalie S. Omattage, Caitlin N. Spaulding, and Scott J. Hultgren

7. The Intracellular Life Cycle of Brucella spp. 101
Jean Celli

8. Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1 113
Sangeeta Tiwari, Rosalyn Casey, Celia W. Goulding, Suzie Hingley-Wilson, and William R. Jacobs, JR.

9. Mycobacterium tuberculosis: Bacterial Fitness within the Host Macrophage 127
Lu Huang, Evgeniya V. Nazarova, and David G. Russell

10. The Wolbachia Endosymbionts 139
Frédéric Landmann

11. Make It a Sweet Home: Responses of Chlamydia trachomatis to the Challenges of an Intravacuolar Lifestyle 155
Sébastien Triboulet and Agathe Subtil

12. Salmonella Single-Cell Metabolism and Stress Responses in Complex Host Tissues 167
Dirk Bumann

13. Manipulation of Host Cell Organelles by Intracellular Pathogens 179
Titilayo O. Omotade and Craig R. Roy

II. Subcellular microbiology

14. The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens 199
Marcela de Souza Santos and Kim Orth

15. Customizing Host Chromatin: A Bacterial Tale 215
Michael Connor, Laurence Arbibe, and Mélanie Hamon

16. Cell Biology of Intracellular Adaptation of Mycobacterium leprae in the Peripheral Nervous System 227
Samuel Hess and Anura Rambukkana

17. Multifaceted Roles of MicroRNAs in Host-Bacterial Pathogen Interaction 247
Carmen Aguilar, Miguel Mano, and Ana Eulalio

18. Modulation of Host Cell Metabolism by Chlamydia trachomatis 267
Marion Rother, Ana Rita Teixeira da Costa, Rike Zietlow, Thomas F. Meyer, and Thomas Rudel

III. Autonomous defense pathways in the cell

19. Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World 279
Charlotte Odendall and Jonathan C. Kagan

20. Recognition of Intracellular Bacteria by Inflammasomes 287
Petr Broz

IV. New technologies to move cellular microbiology to organs and tissues

21. Modeling Infectious Diseases in Mice with a “Humanized” Immune System 301
Yan Li and James P. di Santo

22. A Cinematic View of Tissue Microbiology in the Live Infected Host 315
Agneta Richter-Dahlfors and Keira Melican

23. Cellular Imaging of Intracellular Bacterial Pathogens 325
Virginie Stévenin and Jost Enninga

24. Using a Systems Biology Approach To Study Host-Pathogen Interactions 337
Amy Yeung, Christine Hale, Simon Clare, Sophie Palmer, Josefin Bartholdson Scott, Stephen Baker, and Gordon Dougan

Index 349