- Peter Osborne
- Grant R. Osborne
- John Osborne
- Joanna Osborne
- Lucia Osborne-Crowley
- Ozzy Osbourne
- Sharon Osbourne
- Kelsey Oseid
- Alice Oseman
- Stephen O'Shea
- Mick O'Shea
- Jacqueline Osherow
- Shuzo Oshimi
- Satoshi Oshio
- Andi Osho
- Osho
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- Evan Osnos
- Joel Osteen
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- Nicholas Ostler
- Micol Ostow
- Penelope O'Sullivan
- Suzanne O'Sullivan
- Paul O'Sullivan
- Ronnie O'Sullivan
- Eloghosa Osunde
- Alice Oswald
- Ursula Oswald
- James Oswald
- John N. Oswalt
- Katsuhiro Otomo
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- Kathryn Otoshi
- Otsuichi
- Julie Otsuka
- Shinichirou Otsuka
- Eiji Otsuka
- Jim Ottaviani
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- Jennifer Otter Bickerdike
- Catherine M. Otto
- Yotam Ottolenghi
- Heng Ou
- Piet Oudolf
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- Fulton Oursler
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