Ataxia-Telangiectasia (Nato ASI Subseries H:) de Richard A. Gatti

Ataxia-Telangiectasia: Nato ASI Subseries H:, cartea 77

Richard A. Gatti

Robert B. Painter

en Limba Engleză Paperback – 23 iun 2012

Ataxia-telangiectasia or A-T is a fatal progressiveneurological disease of children. The symptoms indicatedisruptions in the development of such diverse body parts ascerebellum, thymus and chromosomes. The patients are undulysensitive to ionizing radiation, immunodeficient, and athird of them develops cancer. All of this stems fromdefects of a single gene.Provided here is an up-to-date review of all important workin thefield. A wide spectrum of topics is covered, namelygenetics, chromosome 11 mapping, radiobiology,complementation, heterozygote identification, clinicalvariants, biochemistry, and treatment of A-T.

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Specificații

ISBN-13: 9783642782800
ISBN-10: 3642782809
Pagini: 316
Ilustrații: XXIII, 283 p. 18 illus.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.45 kg
Ediția:Softcover reprint of the original 1st ed. 1993
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Nato ASI Subseries H:

Locul publicării:Berlin, Heidelberg, Germany

Cuprins

I. Introduction.- Brief Historical Overview.- II. Isolation of A-T Gene(S).- Cloning and characterization of a candidate gene for A-T complementation Group D.- Precise localization of a gene responsible for ataxiatelangiectasia on chromosome 11q.- How many A-T genes?.- Isolation of human cDNAs that complement the ataxiatelangiectasia phenotype in cultured fibroblasts.- Complementation of the cellular A-T phenotype by gene transfer.- Use of microcell hybrids for analysis of the 11q23 region and improved localization of the A-T Group A/C genes.- AT-like radiosensitive rodent cell mutants: an alternative approach to the isolation of the A-T gene(s).- III. A-T Heterozygotes and Complementation.- Identification of A-T heterozygotes.- Correction of post-gamma ray DNA repair deficiency in ataxiatelangiectasia complementation group A fibroblasts by cocultivation with normal fibroblasts.- The A-T gene does not make a major contribution to familial breast cancer.- Mammography screening for A-T heterozygotes.- IV. Defining the A-T Defect.- Lymphoid V(D)J recombination: accessibility and reaction fidelity in normal and ataxia-telangiectasia cells.- Murine scid cells and human ataxia-telangiectasia cells complement each other’s radiosensitivity.- Ataxia-telangiectasia: defective in a p53-dependent signal transduction pathway.- DNA recombination in the transgenic mouse brain.- V. A-T Variants.- Clinical variants of ataxia-telangiectasia.- Epidemiology of ataxia-telangiectasia in Italy.- Epidemiology of ataxia-telangiectasia in Costa Rica.- Clinical and cellular heterogeneity in ataxia-telangiectasia.- VI. Overviews.- Biochemical defects in ataxia-telangiectasia.- Radiobiology of ataxia-telangiectasia.- Treatment of ataxia-telangiectasia.