In this issue of Urologic Clinics of North America, guest editor Dr. Andrew J. Hung brings his considerable expertise to the topic of Artificial Intelligence in Urology. Alongside technological advancements in artificial intelligence (AI), applications of AI in urology have grown tremendously over the last few years. This special issue highlights areas of particular interest, such as radiomics, pathomics, genomics, and surgery. Top experts in the field cover the current status and also preview future applications, aimed at improved patient outcomes.