The two-volume set LNAI 7894 and LNCS 7895 constitutes the refereed proceedings of the 12th International Conference on Artificial Intelligence and Soft Computing, ICAISC 2013, held in Zakopane, Poland in June 2013. The 112 revised full papers presented together with one invited paper were carefully reviewed and selected from 274 submissions. The 56 papers included in the second volume are organized in the following topical sections: evolutionary algorithms and their applications; data mining; bioinformatics and medical applications; agent systems, robotics and control; artificial intelligence in modeling and simulation; and various problems of artificial intelligence.