This book constitutes the refereed proceedings of the 10th International Conference on Applications and Techniques in Information Security, ATIS 2019, held in Tamil Nadul, India, in November 2019. The 22 full papers and 2 short papers presented in the volume were carefully reviewed and selected from 50 submissions. The papers are organized in the following topical sections: information security; network security; intrusion detection system; authentication and key management system; security centric applications.