This book introduces a novel design methodology which can significantly reduce the ASIP development effort through high degrees of design automation. The key elements of this new design methodology are a powerful application profiler and an automated instruction-set customization tool which considerably lighten the burden of mapping a target application to an ASIP architecture in the initial design stages. The book includes several design case studies with real life embedded applications to demonstrate how the methodology and the tools can be used in practice for accelerating the overall ASIP design process.