Biological immune system (BIS) is a special type of control system that has strong robustness and self-adaptability. This thesis report proposes an artificial immune system algorithm to develop an immune controller. The idea of immune controller is adopted and derived from biological vertebrate immune system, mimicking and imitating of biological immune system which is better known as the artificial immune system. This book show how proposes to apply and implement the algorithm of the artificial immune system (AIS) to develop an immune controller (IC) for three tank level control. There are various models of artificial immune controller (AIC). The most suitable for their particular application is selected. The selected artificial immune controller has the resemblance of a PID controller. The immune controller enhances the performance and stability of the system.