In today’s high-stakes manufacturing environments, leaders don’t need another abstract overview of artificial intelligence or a rehash of Lean fundamentals—they need a hands-on guide that shows exactly how AI can be embedded within the DMAIC framework to drive measurable results.This book delivers just that: a concrete, practitioner-first playbook that integrates AI directly into each phase of DMAIC -— Define, Measure, Analyze, Improve, Control -- rather than treating it as a separate initiative. Drawing on real-world applications from pharmaceuticals, medtech, electronics, and supply chain operations, it offers case-rich insights tailored to the complexity of regulated industries.Readers will find ready-to-use templates, checklists, and governance models designed for immediate implementation. With a balance of academic rigor and executive relevance, this resource is ideal for graduate programs, operational leaders, and innovation teams alike.Whether you're optimizing compliance-heavy workflows or scaling digital transformation, this book equips you to harness AI within a proven Lean Six Sigma structure -- ensuring your solutions are not only innovative, but auditable, scalable, and impactful.