In this issue of Veterinary Clinics of North America: Equine Practice, guest editor Dr. Sushmitha Durgam brings her considerable expertise to the topic of Equine Tendon and Ligament Injuries. Top experts provide comprehensive and up-to-date guidance on tendon/ligament structure/extracellular matrix composition and the role in tendon/ligament function. This issue covers injury mechanisms and biological process that warrant considerations for incorporating and developing therapeutics, cutting-edge diagnostic tools and modalities, and current medical and surgical therapies and rehabilitation strategies for managing tendon and ligament injuries.