In this issue of Veterinary Clinics: Small Animal Practice, guest editors Drs. Helio Autran de Morais, Kate Hopper, and Stephen P. DiBartola bring their considerable expertise to the topic of Advances in Fluid, Electrolyte, and Acid-Base Disorders. The issue is divided into three sections: the first section provides 16 Quick References on various key topics in the field; the second section contains articles on electrolyte and acid-base disorders; and the third section contains articles on fluid therapy.