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A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites (Springer Theses)

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en Limba Engleză Carte Hardback – 26 Apr 2019
This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation.
Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.
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Specificații

ISBN-13: 9783030049898
ISBN-10: 3030049892
Pagini: 396
Dimensiuni: 155 x 235 mm
Greutate: 0.71 kg
Ediția: 1st ed. 2019
Editura: Springer
Colecția Springer
Seria Springer Theses

Locul publicării: Cham, Switzerland

Cuprins

Introduction.- Literature review.- Degradation of bioresorbable composites: the models.- Degradation of bioresorbable composites: tricalcium phosphate case studies.- Degradation of bioresorbable composites: hydroxyapatite case studies.- Experimental degradation study of PLGA–CaCO3 nanocomposites.- Degradation of bioresorbable composites: calcium carbonate case studies.- Conclusions and future work.- Appendix.

Textul de pe ultima copertă

This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation.
Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.

Caracteristici

Nominated as an outstanding Ph.D. thesis by the University of Cambridge
 
Provides a comprehensive, up-to-date database of quantitative composite degradation data mined from existing literature
 
Includes a detailed description of a mathematical modelling framework for the degradation of bioresorbable composites and the analysis of 107 different composite case studies 

Provides new insights into the interwoven factors controlling degradation