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A Guide to Sample Size for Animal-Based Studies

Autor Penny S Reynolds
en Limba Engleză Paperback – 12 sep 2023
Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs Replacement, Reduction and Refinement the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-Based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "right-sizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: * Step-by-step guidance in diverse methods for approximating and refining sample size * Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies * Sample size approximation methods for different types of data binary, continuous, ordinal, time to event and different study types description, comparison, nested designs, reference interval construction and dose-response studies * Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-Based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.
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Specificații

ISBN-13: 9781119799979
ISBN-10: 111979997X
Pagini: 288
Dimensiuni: 216 x 280 x 16 mm
Greutate: 0.74 kg
Editura: Wiley
Locul publicării:Chichester, United Kingdom