Long time friends Leslie and Liz are smart, talented and successful women. In their mid-fifties, the two have what many in their Baby Boomer generation have striven for: successful careers, beautiful homes, country club memberships, and financial security. In fact, they have everything mature women could want, including loving (if sometimes clueless) husbands. But lately, something seems not quite right. The two self-crowned "Queens" often talk and dream of shucking the mantles of their corporate and suburbia worlds, where people and circumstances require them to pretend to be people they aren't. And they've joked for years about running away in a motor home. But they never did. Until on one ordinary day, and after some impulsive, secret preparations, and brief notes to their families, the two pack up their newly acquired motor home, and begin the long awaited adventure they've dreamed of for so long. The road life they adopt teems with new experiences, new friends, and many challenges. But that's not all. For along the way, it is not just their original plans and dreams that are altered. Their very lives and relationships take on new meaning, as well. But with this experience and adventure comes yet more questions to be answered. Should they stay on the road? Will their husbands ever understand? Will they be safe? What else waits beyond that horizon? And most importantly, can they or will they ever go home again?