The authors warn governments, societies and humanity about the future of Amazonia. It is dying. Who will save Amazonia? The world is at war with COVID-19, climate change and social inequality. This book shows that Amazonia is a key entity in the victory of humanity against these three "plagues" of modernity. A worldwide mobilisation is needed to stop its cultural and ecological destruction. Its full submission to the market and to predatory privatisation contribute to this process that has global impact. Many diseases and pandemics could spread throughout the world as a result of continued destruction of this incredibly biodiverse region. It has about 163 indigenous peoples, over 2000 rivers and 400 billion trees. It is important for world food security, climate change mitigation and bioindustry. This study puts the need for its transformation into the world heritage. Links, controversies and challenges about Amazonia's sustainable development and nature, territory, culture, environmental justice, economics, work, bioeconomy, COVID-19, climate change and environmental protection are debated in the perspective aimed at improving quality of life of their native populations. Its relations with Christian foundations are also shown. Its importance for humanity is analysed from the perspective of sustainability. The book presents denunciations on the destructive interventions made by the Brazilian government on its peoples and biomes. This tragedy has been aggravated by the dispersion of COVID-19 in the region. This book shows that Brazilian Amazonia's future is an announced world tragedy. Who will save Amazonia? According to Marclio and Marilene, the responsibility of its sustainable protection is on us all.