The author is completely perplexed by the wonders in this world and far beyond. At the same time he realizes that this impressive beauty often goes together with incredible human and animal suffering and misery. His reflections are summarized in four different chapters: on Nature, the Universe, Intelligence, and the ultimate question: Why we are here. Of course, his answers are very personal and far from complete. Perhaps, more questions are asked than answers can ever be given. The material for his reflections was borrowed from the scientific literature, his own research, mainly in the biomedical field, his great interest in astronomy and cosmology, and from books of wisdom. The main source for his reflections are the different writings of prophets, historians and poets in the Bible.