This book is based on a collection of homework problems, design projects and sample interview questions for the VLSI High-Speed I/O Circuits class (EEE598) the author offered in the School of Engineering at Arizona State University. The materials cover various aspects of the design, analysis and application of VLSI high-speed I/O circuits. This book is intended to be used together with the VLSI High-Speed I/O Circuits textbook by the same author. It can also be used alone for the experienced readers.