When Doctor Sally Lawson examines a patient arriving in Northwestern Hospital's emergency room, she immediately understands the implications of the strange combination of symptoms. Her hospital and the city are about to fight a battle not seen since the Chicago Fire. Sally and her husband, Detective Dan Lawson, along with the FBI and CIA, are committed to the search for those responsible. The emerging facts point to the involvement of the Iranian Government, and if proven, the attack is certainly an act of war.