Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organized into six parts, covering foundational concepts, roles in aging and metabolism, disease pathology, therapeutic strategies, future research directions and potential challenges. Topics include the structure and evolution of sirtuins, their mechanisms of action, and their impact on neurodegenerative diseases, cardiovascular health, and cancer. It also features detailed chapters on sirtuin modulators, drug discovery, the latest technologies and tools in the field, emerging trends, and the challenges, ethical considerations and future directions of sirtuin-targeted therapies. The content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. “Unlocking Sirtuins” offers an in-depth overview of sirtuin biology, bridging fundamental science with clinical application. It serves as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine and related fields.

• Provides an interdisciplinary overview of sirtuin biology, bridging foundational science with translational research
• Facilitates the development of sirtuin-targeted therapies to target a variety of diseases including cancer and neurodegenerative disorders
• Highlights cutting-edge tools and technologies for sirtuin analysis
• Includes case studies and step-by-step procedures to support scientists in their own research