This book discusses the topic of thrombophilia with the help of advanced information. Thrombophilia(s) is a state of high tendency to form blood clots. This state can be acquired or inherited which is the main reason behind this term being often used in plural. People suffering from thrombophilia have greater chances of acquiring thromboembolic complications, like pulmonary embolism, deep venous thrombosis or cardiovascular complexities, such as stroke or myocardial infarction. But these complications are rare and it is possible that these individuals might never face clotting problems throughout their life. The enhanced blood coagulability is intensified under conditions of extended immobility, surgical intervention, especially at the time of pregnancy and puerperium, and the use of estrogen contraception. This has led to the reason why numerous obstetricians-gynecologists have engaged themselves in this field apart from hematologists: women are more commonly at risk. The availability of novel lab tests for hereditary thrombophilia(s) has given way to a new era delving on primary healthcare, epidemiology, prevention and prophylaxis, so that thrombophilia is one of the most researched topics in contemporary medicine.