Thiadiazoles: Advances in Research and Applications opens by discussing how, due to antioxidant properties, influence on muscarinic acetylcholine receptors, and inhibition of acetylcholinesterase activity, 1,2,4-thiadiazole-class compounds can be considered as potential drugs in the treatment of disorders connected with the central nervous system, such as Alzheimer's disease. An overall review of the synthesis, biological activity, solubility, lipophilicity, and membrane permeability of a number of 1,2,4-thiadiazole derivatives with different substituents in the structure is presented. Additionally, the authors provide an overview of the applications of thiadiazoles in the corrosion inhibition of metals and alloys. A detailed review of the literature on thiadiazole derivatives as corrosion inhibitors for acidic and neutral environments for different metallic substrates is also provided.