The Swiss author Johann Georg Zimmermann (1728–1795) is widely regarded as a prototype of the physician-cum-writer. The present monograph stems from the research field of literary anthropology. It begins by investigating Zimmermann’s views on human destiny in the contemporary context. Subsequently five sets of issues are addressed as the basis for an analysis of his magum opus Über die Einsamkeit (On Loneliness) (1784/85). In an attempt to situate it in the contemporary landscape, the analysis inquires into the literary features of Zimmermann’s oeuvre against the background of the epoch in which it was written. It also sets out to pinpoint links between Zimmermann’s works and the history of medicine and science, as well as delineating the author’s specific brand of pious Enlightenmentalism.