In the not too distant future, an ancient bacterium is discovered by a group of scientists in the depths of the Amazon River basin. Found to have miraculous healing powers on the human brain, it fills the research team, led by noted Neurologist Dr. Lemuel Sanderson, with tremendous hope. That is until something goes terribly wrong. An unknown force is creating an army of undead bent on the destruction of the human race. Dr. Sanderson, with the assistance of an eccentric billionaire, sets out to track down one of his former test subjects. One he firmly believes holds the key to putting an end to this nightmare. Major Charles "Butch" Bradley has been entrusted with the evacuation of Washington D.C. Along the way he rescues a group of college students, a mother and her two children, and a stubborn outdoorsman with a penchant for blowing things up. He is now responsible for their safety as he and his men navigate this dangerous new world, looking for a safe haven. As events unfold, the Major and Dr. Sanderson find themselves on a collision course whose outcome may determine the fate of humanity.