The global health community has reached a critical juncture in that now, more than ever, the knowledge, innovative technologies, and proven tools to help millions of people in need are within reach. Despite demonstrated success in tackling certain health issues, a wide gap remains between what can be done with existing knowledge and what is actually being done in disadvantaged communities. Neither the U.S. government nor any one U.S. organization can achieve global health acting alone, but only as part of a shared global endeavor/campaign. The U.S. Commitment to Global Health examines ways in which the United States could contribute to advances in global health, including the following four areas of action: 1) Generate and share knowledge to address problems endemic to poor countries 2) Invest in people, institutions, and capacity-building in resource-poor settings 3) Increase both the quantity and the quality of U.S. financial commitments to global health 4) Be a respectful partner and leader. Addressing the vision for a renewed U.S. commitment to global health, this book communicates specific recommendations not just for the U.S. government, but also for several nongovernmental sectors, including foundations and philanthropies, academia, nonprofit organizations, and the commercial sector.